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Wazana A, Bresnahan M, Kline J: The autism epidemic: fact or artifact

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IGF-1R activates various intracellular secondary messenger pathways upon binding its ligands (IGF-1, IGF-2, and insulin at supraphysiological concentrations)

This cellular and molecular damage accelerates the aging process, driving the onset of age-related diseases such as cardiovascular disorders, neurodegenerative diseases, diabetes, and inflammatory conditions